The neutral theory, formally known as the neutral theory of molecular evolution, was independently proposed by M. Kimura in 1968 (see Kimura 1983, cited under General Overviews, the Neutral Hypothesis of Phenotypic Evolution, and Outstanding Questions; Kimura 1994, cited under General Overviews; and Kimura 1968, cited under Origin of the Theory) and J. L. King and T. H. Jukes in 1969 (see King and Jukes 1969, cited under Origin of the Theory). The chief tenet of the theory is that most genetic differences between species and polymorphisms within species are selectively neutral and result from mutation and genetic drift. This view sharply contrasts that of neo-Darwinists, who maintain that most of these variations are adaptive. While the neutral theory has been controversial since its debut, the neutralist-selectionist debate has been largely healthy in that it greatly stimulated the development of rigorous neutrality tests, and it is now customary to invoke adaptive explanations only when a null hypothesis of neutrality is rejected. The neutral theory has been revised and broadened in a number of ways since the 1990s, including the emphasis of nearly neutral mutations in the nearly neutral theory, expansion to evolutionary explanations of genomic architectures, and application to phenotypic evolution. While these studies are not without contention, the idea that genetic drift, rather than adaptation, could explain origins of nonrandom patterns in biology has had profound impacts on many biologists’ view of evolution and the living world. The neutral theory remains the sole paradigm-changing conceptual revolution in evolutionary biology since the maturation of the neo-Darwinism in the 1950s.
There are a few books on the neutral theory, and Kimura 1983 remains the most comprehensive and authoritative book on the topic. Kimura 1994 is an edited volume of Kimura’s original papers on neutral theory and his underlying population genetic work. Crow and Kimura 1970 is a classic textbook of population genetic theory and deals with many fundamental concepts; it is highly useful for understanding the population genetic basis of the neutral theory. Ohta 2009 is a Japanese book on nearly neutral theory, which asserts that most intraspecific and interspecific genetic variations are not strictly neutral but are nearly neutral. Lynch 2007 argues that fixations of slightly deleterious mutations by drift led to the origins of various complex genomic architectures. Nei 2013 argues for the role of mutation and drift in evolution in general. Textbooks of molecular evolution that contain lucid discussions about the neutral theory and related topics include Nei 1987 and Li 1997.
Crow, J. F., and M. Kimura. 1970. An introduction to population genetics theory. Caldwell, NJ: Blackburn.
A classic textbook of theoretical population genetics, it provides many theoretical results pertaining to the neutral theory.
Kimura, M. 1983. The neutral theory of molecular evolution. Cambridge, UK: Cambridge Univ. Press.
In this single most important book of evolutionary biology since the 1960s, the neutral theory is lucidly, comprehensively, and forcefully argued for by its chief advocate.
Kimura, M. 1994. Population genetics, molecular evolution, and the neutral theory: Selected papers. Chicago: Univ. of Chicago Press.
An edited volume of Kimura’s original papers, many key to the development of the neutral theory.
Li, W.-H. 1997. Molecular evolution. Sunderland, MA: Sinauer.
A lucid and comprehensive textbook on molecular evolution, it discusses many topics highly relevant to neutral theory, such as nucleotide and amino-acid substitution rates and the molecular clock.
Lynch, M. 2007. The origins of genome architecture. Sunderland, MA: Sinauer.
The role of nearly neutral mutations in the origins of genomic complexity is forcefully argued for in this monograph.
Nei, M. 1987. Molecular evolutionary genetics. New York: Columbia Univ. Press.
A pioneering textbook of molecular evolutionary genetics by a longtime supporter of the neutral theory.
Nei, M. 2013. Mutation-driven evolution. Oxford: Oxford Univ. Press.
The author proposes a central role of mutation (and drift) rather than selection in evolution in general.
Ohta, T. 2009. Nearly neutral theory of molecular evolution: Evolutionary models of selection and chance. Tokyo: Kodansha.
A text on the nearly neutral theory, written by the proposer of the theory. In Japanese.
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- Adaptive Radiation
- Ancient DNA
- Behavioral Ecology
- Cognition, Evolution of
- Constraints, Evolutionary
- Convergent Evolution
- Cooperation and Conflict: Microbes to Humans
- Cooperative Breeding in Insects and Vertebrates
- Cryptic Female Choice
- Darwin, Charles
- Disease Virulence, Evolution of
- Epigenetics and Behavior
- Evidence of Evolution, The
- Evolution and Development: Genes and Mutations Underlying ...
- Evolution, Cultural
- Evolution of New Genes
- Evolution of Plant Mating Systems
- Evolution of Specialization
- Field Studies of Natural Selection
- Founder Effect Speciation
- Frequency-Dependent Selection
- Fungi, Evolution of
- Gene Duplication
- Gene Expression, Evolution of
- Gene Flow
- Genetics, Ecological
- Genome Evolution
- Geographic Variation
- History of Evolutionary Thought, 1860-1925
- History of Evolutionary Thought before Darwin
- Human Behavioral Ecology
- Human Evolution
- Hybrid Speciation
- Hybrid Zones
- Inclusive Fitness
- Innovation, Evolutionary
- Kin Selection
- Landscape Genetics
- Landscapes, Adaptive
- Language, Evolution of
- Macroevolutionary Rates
- Male-Male Competition
- Mate Choice
- Medicine, Evolutionary
- Molecular Clocks
- Molecular Phylogenetics
- Natural Selection in the Genome, Detecting
- Neutral Theory
- Niche Construction
- Niche Evolution
- Origin and Early Evolution of Animals
- Origin of Life, The
- Paradox of Sex
- Parental Care, Evolution of
- Personality Differences, Evolution of
- Phenotypic Plasticity
- Phylogenetic Trees, Interpretation of
- Polyploid Speciation
- Population Genetics
- Population Structure
- Psychology, Evolutionary
- Punctuated Equilibria
- Quantitative Genetic Variation and Heritability
- Reproductive Proteins, Evolution of
- Selection, Directional
- Selection, Disruptive
- Selection, Natural
- Selection, Sexual
- Selfish Genes
- Sexual Conflict
- Sexual Selection and Speciation
- Speciation Genetics and Genomics
- Speciation, Sympatric
- Species Concepts
- Sperm Competition
- Systems Biology
- Taxonomy and Classification
- Tetrapod Evolution
- Trends, Evolutionary
- Wallace, Alfred Russel